Caliercortin – 50 ml (Calier Lab) (ARG)

Caliercotin (Calier Lab) it´s an Anti-inflammatory, anti-exudative, anti-proliferative and anti-allergic, based on Dexamethasone for horses, cattle, pigs, sheep, goats, cats and dogs.

Composition:
Dexamethasone (21 sodium phosphate) 0.4 g.
Aqueous Excipient c.s.p. 100 ml

Action:
Anti-inflammatory, anti-exudative, anti-proliferative and anti-allergic. Dexamethasone is a corticosteroid with a mechanism of action and intensity of effect 4 to 5 times higher than the same concentration of a crystalline prednisolone suspension.
With CALIERCORTIN you get a hormonal effect and a thermacodinic effect The hormonal action consists in the regulation of the metabolism of carbohydrates: it increases glycemia, stimulates the neoformation of sugars from proteins and fats, increases hepatic glucose. It has antitoxic and antiallergic action.
The pharmacodynamic action consists of an intense inhibition of the mesenchymal, anti-inflammatory, anti-exudative and antiproliterative reaction.

Indications:
In all target species, against inflammations caused by infections, allergies, trauma or other etiologies. Shock and circulatory collapse, bovine ketosis.

Contraindications:
Don´t administer to animals with bacterial diseases without concomitant antibiotic therapy, fungal or viral infections, renal and / or hepatic insufficiency, congestive heart failure, osteoporosis, bone fractures, diabetes mellitus, degenerative ocular diseases or corneal ulcers, hyperadrenocorticalism, animals undergoing immunological treatment.
Do not administer in pregnant females during the last third of pregnancy, as it can lead to premature delivery followed by dystocia, fetal death, placental retention and metritis. Dairy production of lactating animals may temporarily decrease with the administration of Dexamethasone.
Do not administer together with:
-Antidiabetics: the hyperglycemic action of corticosteroids can counteract the anti-diabetes effect.
-Barbiturates: parenterally, they can lead to a loss of the therapeutic efficacy of corticosteroids.
-Diuretic potassium deplectors: they can lead to significant hypokalemia with the consequent risk of cardiac, muscular pathological manifestations.
-Indomethacin: administered parenterally, it can lead to an increase in the incidence of gastrointestinal disorders and especially peptic ulcer.
-Salicylates: may lead to a plasma decrease in salicylates. In addition, the harmful effects on the gastric mucosa can be enhanced.
-Antihistamines: increase the degradation of Dexamethasone. Do not administer concomitant therapy with other corticosteroids.

In case of infectious or parasitic diseases, apply together with specific antibiotics or antiparasitic.
Prolonged use of the recommended doses for weeks or months may cause symptoms of Cushing, and abrupt discontinuation of treatment results in atrophy of the adrenal glands (hypoadrenocorticism).
Important: It is up to the veterinarian to establish emergency therapy in the cases cited contraindicated for use.

Restrictions of use:
Do not administer to horses whose meat is intended for human consumption.
For meat the waiting time is 5 days, for milk it is 3 days.

Collateral damage:
In cases of infections, the symptoms of it can be masked, such as pyrexia, laxity and lack of appetite.
It decreases organic defenses by predisposing the animal more easily to microbial infections. It causes delayed wound healing.
It can produce weakness of striated musculature.
In dogs and cats it can cause an increase in the enzymes Serum Alkaline Phosphatase (SAP) and Serum Pyruvic Glutamic Transaminase (SGPT), weight loss, anorexia, diarrhea (sometimes bloody), vomiting, polydipsia and polyuria. Euphoria and some changes in animal behavior have also been observed with improved attitude.
In horses, a dose greater than 5 mg / animal can cause lethargy, which usually remits within 24 hours. In some cases, it can cause laminitis.

Dosage:
Administration intramuscularly, subcutaneously or intravenously.
Cattle, sheep, goats, pigs and horses: 0.005-0.02 ml per kg of single dose live weight.
Canine: 0.0125-0.05 ml per kg of live weight single dose.
Feline: 0.025-0.075 ml per kg of live weight single dose.
Intra-articular administration:
Large animals: 0.5-2.5 ml.
Small animals: 0.125-1.25 ml, repeat if necessary, every 24-48 hours, for a maximum period of 5 days.

Dose for Horse & Camel in Race: 
Intramuscular and intravenous (IV or IM)
for race, average recommended dose:
– Camel: 5 doses, each dose every 1 day, 5 ml / day
– Horse: 5 doses, each dose every 1 day, 7 ml / day
last dose 5 days before the race

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Dexamethasone Sodium 21 Phosphate 4 mg/ml. Excellent pain Killer and antiinflmmatory. www.horseandcamelsupplies.com

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